Are you a patient or caregiver to someone dealing with these poor blood flow symptoms: leg or foot pain, gangrene, or foot ulcers?

If so, you may be eligible to participate in an exciting international research study. 

How We Can Help

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Hundreds of physicians at sites in the US, Canada, Finland, Italy, New Zealand and elsewhere specialize in treating CLI. These doctors, their research nurses, and coordinators on “BEST-CLI teams” provide high quality, long-term care to patients who enroll in the study.

BEST-CLI is a study for people with peripheral arterial disease (PAD).

 

A condition called Critical Limb Ischemia (CLI), can cause fatty deposits to build up on the inside of blood vessels on one or both legs. This reduces the flow of oxygen-rich blood to the legs and, when severe, may cause pain even when resting; skin sores (ulcers) on the leg and/or foot; and/or gangrene (death of tissue).

Over 130 leading hospitals in 5 countries around the world are participating in the BEST-CLI Trial - that's nearly 1000 physicians worldwide

 

1585 patients have participated so far

We need 515 more to reach 2100

What will happen during the study?

Participants in this study are randomly assigned - not by the doctor’s or patient’s decision - to one of two treatment groups, endovascular therapy (angioplasty/stenting) [Group A] or surgical therapy [Group B].

If assigned to Group A (below) the blockage(s) in your artery will be opened with a balloon and a wire mesh stent may be inserted permanently to maintain the opening.

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If assigned to Group B (below) a detour or “bypass” around the blockage in the blood vessel will be made by insertion of a vein or a tube made of synthetic material.

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Both therapies - endovascular and surgical bypass - are internationally accepted standards of care.